My interests lie at the interface between physics and biology. Previously, my work has focused on DNA replication – the most critical process for every living organism. More recently, I have also become interested in cellular mechanics during tissue formation as well as how cellular differences arise on the chromatin level of early embryonic cells.
So far, my research on DNA replication contributes to the elucidation of the physical principles which govern faithful and on-time DNA duplication each time a cell divides. This is done using stochastic modelling of protein-DNA interaction and DNA replication replication kinetics, combining theoretical techniques from statistical physics with numerical approaches, for example Monte-Carlo simulations.
At the Max-Planck-Institute, I continue working on physical problems in biology, aiming to further the understanding of stochastic processes involved in the macromolecular building blocks of life, and identify the constraints for living organisms. Specifically, I look at tissue mechanics with the help of a cellular vertex model, and theoretically investigate what causes the genome activation of the early zebrafish embryo to become activated during its early development.